There are several factors that play a role in the development of the osteoarthritis. These include:

• Genetic factors

• Gender and hormonal status

• Family history

• Being overweight

• Joint Injuries

• Work and leisure factors (repetitive occupational trauma)

• Frequent squatting or kneeling

• Jobs that involved heavy lifting

• Climbing stairs

• Strenuous exercise (Marathon runners, however, have a relatively low rate of osteoarthritis in general. Some scientists speculate that running enhances cartilages health)

• Bone infection

• Joint shape (such as mismatched surfaces on the joints, legs of unequal length or skewed feet)